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The PAC‐1 binding capacity in patients with and without platelet transfusion. PAC‐1 binding was analysed in both groups of patients based on MFI. Results did not show significant changes in PAC‐1 binding (MFI) in patients without platelet transfusion; however, a significant increase was demonstrated in patients with platelet transfusion 24 h after surgery (A). When the results of two groups were compared side by side, a significant difference in PAC‐1 binding was seen in patients receiving platelets compared to the other group 24 h after the surgery (B). bef; before, IM‐aft; immediately after, 2 h‐aft; 2 h after, 24 h‐aft; 24 h after, 1w‐aft; 1 week after, ns; not significant. For comparison of the parameters on different days in each group, data were analysed by the Kruskal–Wallis test with Dunn's multiple comparison tests. The Mann–Whitney U test was also applied to compare parameters between the two groups (* p < 0.05, ** p < 0.01, *** p < 0.001). ( n = 20).

Journal: Journal of Cellular and Molecular Medicine

Article Title: Platelet transfusion enhances pro‐aggregatory status shortly after coronary artery bypass grafting ( CABG while modulating platelet pro‐inflammatory state 1‐week post‐surgery

doi: 10.1111/jcmm.18573

Figure Lengend Snippet: The PAC‐1 binding capacity in patients with and without platelet transfusion. PAC‐1 binding was analysed in both groups of patients based on MFI. Results did not show significant changes in PAC‐1 binding (MFI) in patients without platelet transfusion; however, a significant increase was demonstrated in patients with platelet transfusion 24 h after surgery (A). When the results of two groups were compared side by side, a significant difference in PAC‐1 binding was seen in patients receiving platelets compared to the other group 24 h after the surgery (B). bef; before, IM‐aft; immediately after, 2 h‐aft; 2 h after, 24 h‐aft; 24 h after, 1w‐aft; 1 week after, ns; not significant. For comparison of the parameters on different days in each group, data were analysed by the Kruskal–Wallis test with Dunn's multiple comparison tests. The Mann–Whitney U test was also applied to compare parameters between the two groups (* p < 0.05, ** p < 0.01, *** p < 0.001). ( n = 20).

Article Snippet: The human monoclonal antibodies CD41 (FITC/PE‐conjugated), CD62P (PE‐conjugated), CD40L (FITC‐conjugated) and PAC‐1 (FITC‐coupled activation‐specific anti‐GPIIb/IIIa antibody) were supplied by BD Pharmingen.

Techniques: Binding Assay, Comparison, MANN-WHITNEY